Corrositex Continuous Time Monitor Assay
The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test material.
A test material is evaluated based on its penetration through the biobarrier membrane into a Chemical Detection System (CDS). The time required for the test material to break through the biobarrier and into the CDS is determined. A U.S. Department of Transportation (USDOT) packing group is assigned based on the break through time.
The Corrositex® assay is presently the only in vitro assay approved by the U.S. Department of Transportation for testing potential corrosive materials and assigning packing group categories.
Assay Design: Quick Facts
Assay Model: proprietary biobarrier membrane
Detection Agent: CDS (chemical detection system)
Endpoint: the time required for a corrosive material to break through the membrane